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For research use only.

Adipotide

Fat-vessel-targeting peptide
What it is

Adipotide is a lab-made peptide designed to home to blood vessels in white fat and trigger their breakdown, studied in animals as a way to reduce fat tissue.[1][2]

Origin: Built from a fat-vasculature-homing sequence (CKGGRAKDC) found by phage display, linked to a death-inducing motif; early work came from Kolonin, Arap, Pasqualini and colleagues.[1]

What researchers study it for

Research areas

Published animal studies point to several research angles.

  • Targeted reduction of white fat by damaging its blood supply in mice[1]
  • Weight loss and improved insulin resistance in obese monkeys[2]
  • Broader questions about fat-vessel targeting as a metabolic research tool[2][3]

Evidence level

Level 1 of 4: Lab and animal onlyPublished adipotide work is in mice and obese monkeys, not controlled trials in people.[1][2]

Why so few human trials?

Cautions

Studies and regulators point to several reasons for care.

  • Findings come from animal models; human safety and effectiveness are not established in published trials[1][2]
  • Targeting blood vessels in fat raises theoretical concerns about off-target vessel effects that have not been settled in people[1][2]

Adipotide is not FDA approved.

Also called

Adipotide goes by several names.

  • A prohibitin-targeting peptide / fat-targeting proapoptotic peptide in the research literature[1][2]
  • CKGGRAKDC-linked peptidomimetic constructs used in the monkey study[2]

Good to know

Adipotide is studied for going after the blood supply of white fat cells, not for acting like an appetite hormone such as GLP-1.[1][2]

Handling

Storage basics General

These general basics apply to most freeze-dried research peptides.

Most research peptides come as a freeze-dried powder in a sealed vial
Unmixed vials are generally kept cold, dry, and away from light
Mixed solutions are generally refrigerated, since they are less stable than the dry powder
Peptides 101For mixing basicsNPL Dose CalculatorTo work out concentration after mixing
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Sources and studies

These studies and official pages are the research behind this profile.