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For research use only.

CJC-1295

GHRH analog · with or without DAC
What it is

CJC-1295 is a lab-made version of GHRH, the brain’s "go" signal that tells the pituitary gland to release growth hormone.[1][2]

Pathway: GHRH. CJC-1295 is a lab-made version of the first 29 amino acids of natural GHRH, the brain’s "go" signal for growth hormone, with four amino acids swapped.[1][2]

With or without DAC: DAC is an add-on that makes CJC-1295 last much longer in the blood, so it’s taken less often.[1][2] The core peptide and its pathway are the same either way.[1]

Origin: Identified in 2005 by Jetté and colleagues at ConjuChem in Montreal as a long-lasting analog of human GRF(1-29) that sticks to albumin in the blood.[1]

What researchers study it for

Research areas

Human and animal studies have focused on how it raises the body’s own growth hormone signal.

  • Longer GH and IGF-I rises after subcutaneous injection in healthy adults[2]
  • Preserved pulsatile GH release while overall GH and IGF-I increased[3]
  • Acute GH release in rats after the albumin-binding form was given[1]

Evidence level

Level 3 of 4: Small human trialsRandomized, placebo-controlled studies in healthy adults showed sustained GH and IGF-I increases with the long-acting (DAC) form.[2][3]

Why so few human trials?

Cautions

Studies and regulators point to several reasons for care.

  • FDA has identified serious adverse events associated with CJC-1295, including increased heart rate and a systemic vasodilatory reaction, and says available clinical data are limited[4]
  • The published human studies tested the long-acting form with DAC, not a separate no-DAC product[2][3]

CJC-1295 is not FDA approved.[4]

Also called

CJC-1295 goes by several names.

  • Long-acting GHRH analog[2][3]
  • Modified GRF (1-29), a common market name for the core without DAC
  • hGRF(1-29) analog with an albumin-binding group (the DAC form)[1]

Often stacked with

Ipamorelin. CJC-1295 and ipamorelin are paired because they flip two different switches for GH release, so one doesn’t just repeat the other.[1][5]

IpamorelinTogether:StackIpamorelin →

Good to know

The human studies of CJC-1295 tested the form with DAC.[2][3]

Handling

Storage basics General

These general basics apply to most freeze-dried research peptides.

Most research peptides come as a freeze-dried powder in a sealed vial
Unmixed vials are generally kept cold, dry, and away from light
Mixed solutions are generally refrigerated, since they are less stable than the dry powder
Peptides 101For mixing basicsNPL Dose CalculatorTo work out concentration after mixing
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Sources and studies

These studies and official pages are the research behind this profile.