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For research use only.

NAD+

Nicotinamide adenine dinucleotide · not a peptide
What it is

NAD+ (nicotinamide adenine dinucleotide) is a natural coenzyme, a dinucleotide your cells use to move electrons and to power enzymes that repair DNA and help regulate aging pathways.[1] It is not a peptide (not a chain of amino acids), and Neo Peptide Labs still includes it in the library because it sits at the center of the same energy and aging questions as the mitochondrial peptides around it.[1]

What researchers study it for

Research areas

Much of the human research uses NAD+ precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), or short NAD+ infusions, rather than giving NAD+ itself as a peptide-style research vial.[2][3][4]

  • Tissue NAD+ tends to fall with age in human samples, alongside rises in markers of DNA damage[5]
  • Oral NR raised blood NAD+ in healthy middle-aged and older adults in a controlled trial[2]
  • Oral NMN raised blood NAD+ and was studied for physical performance in healthy middle-aged adults[3]
  • Oral NMN improved muscle insulin sensitivity in women with prediabetes who were overweight or obese[6]
  • A small pilot tracked how an intravenous NAD+ infusion changed NAD+ metabolites in plasma and urine[4]

Evidence level

Level 3 of 4: Small human trialsControlled studies of NAD+ precursors (NR and NMN) and a small intravenous NAD+ pilot have been run in modest numbers of people.[2][3][4][6]

Why so few human trials?

Cautions

Studies and regulators point to several reasons for care.

  • Much of the clinical work tests precursors (NR or NMN), so findings do not automatically transfer to every NAD+ research form[1][2][3]
  • Long-term safety of raising NAD+ for general use is still being mapped in larger trials[1]
  • NAD+ itself is not an FDA-approved drug for aging, energy, or metabolic disease[1]

Also called

NAD+ goes by several names.

  • Nicotinamide adenine dinucleotide[1]
  • Coenzyme I, an older lab name for NAD+[1]
  • Its reduced partner NADH, which carries the electrons NAD+ accepts[1]

Often stacked with

SS-31 and MOTS-c. Researchers study all three for overlapping questions about mitochondria and cell energy, though they act through different tools.[1][7][8]

SS-31MOTS-c

Good to know

NAD+ is built from two nucleotide halves (one with nicotinamide, one with adenine), which is why chemists call it a dinucleotide, not a peptide.[1]

Handling

Storage basics General

These general basics apply to most freeze-dried research materials in this library.

Most research vials come as a freeze-dried powder in a sealed vial
Unmixed vials are generally kept cold, dry, and away from light
Mixed solutions are generally refrigerated, since they are less stable than the dry powder
Peptides 101For mixing basicsNPL Dose CalculatorTo work out concentration after mixing
Go deeper

Sources and studies

These studies and official pages are the research behind this profile.